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The peptide appears to upregulate cell motility and migration by interacting with the cellular cytoskeleton, specifically inhibiting the polymerization of globular actin (G-actin) into filamentous actin (F-actin)

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Sirtuin 1 (SIRT1) negatively regulates GH-induced IGF-1 production in the liver by directly inhibiting signal transducer and activator of transcription 5 (STAT5) activation, which causes GH resistance under prolonged fasting, starvation, and malnutrition [6]